Nghiên cứu tổng hợp chọn lọc 10β-Azidoartemisinin

Abstract

This paper presents a simple method for selective synthesis of the key compound, 10β-azidoartemisinin. The compound 10β-azidoartemisinin was selectively synthesized by the reaction of dihydroartemisinin (2) with NaN₃, KI using ZnCl₂ as a catalyst at 0-5 ^oC. The structure of 10β-azidoartemisinin was elucidated based on ¹H, ¹³CNMR spectrum and known documents.